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Alcohol is often treated as harmless—as long as we do not drink “too much.” But we now know that is not true. Every drink exposes the body to acetaldehyde, a toxic by-product The closest structural homolog with an experimentally determined structure is human LH3/PLOD3, whose central accessory (AC) domain shares only 24% sequence identity, but shows very similar structural arrangement with RMSD of 1.2 Å (Supplementary Fig Buy More and Save:1 Box $69.00 Microsoft https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10719-021-09980-0/MediaObjects/10719_2021_9980_Fig1_HTML.png
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