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Upregulation of CD38 in patients with SSc, resulting from its induction by cytokines such as TGF-ß, IL-6 and senescent cell-derived SASP enriched in the fibrotic tissue microenvironment, will promote NAD + consumption and decline, which in turn impairs the function of sirtuins and other NAD + -dependent cellular enzymes
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[DOI] [PubMed] [Google Scholar] 231.Hahn TM, Breininger JF, Baskin DG & Schwartz MW Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons
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