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Lastly, beta-hydroxyacyl-CoA is oxidized to beta-ketoacyl-CoA while NAD+ is reduced to NADH, which follows the same process as the oxidation of malate to oxaloacetate

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However, the MTT assay conducted showed similar or lower cytotoxicity of nano FLT in comparison to plain FLT due to higher accessibility of the latter and slower release of the former ( A ternary nanoassembly was formulated by Zagami et al