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WHAT THE EVIDENCE IS The FDA briefing document dated 5/11/2026 identified five published human studies of BPC-157, totaling roughly 80 subjects: 24 healthy volunteers given rectal enemas, approximately 26 patients with ulcerative colitis, 17 patients with knee pain (given a compounded combination with thymosin beta-4), 12 patients with interstitial cystitis, and 2 healthy volunteers given intravenous infusions

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Studies have shown that EGCG, the main component of catechin, inhibits programmed cell death ligand 1 (PD-L1) in lung cancer cells induced by interferon (INF-γ) and EGF, even JAK2/STAT1 expression (110)