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In terms of metabolic pathways, single eukaryotic strain often perform better due to compartmentalization within the eukaryotic cell, which plays a crucial role in mitigating the effects of the metabolic cliff

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These epigenetic alterations may impair transcription factor recruitment and alter expression of drug-metabolizing genes such as CYP1A1, ultimately impacting drug metabolism and pharmacokinetics (Wang et al., 2018)