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Financial & competing interests disclosure This project was funded through the North of England Children's Cancer Research Fund (NECCR), the Wellcome Trust & Wellcome Trust Institutional Strategic Support Fund, the Rank Prize Fund and the JGW Patterson Foundation, grant number BH152502
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Inflammation – haptocorrin levels can increase due to granulocyte activation or as an acute phase response Decreased clearance: Renal failure – decreased clearance of transcobalamin–B12 complexes Mechanism: Most elevated B12 is not free or biologically active , but rather bound to haptocorrin , which has a long half-life and is increased in certain diseases
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