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In people with liver dysfunction, the production of oxalates via lactate dehydrogenase is increased while AGXT (more below on this gene) is decreased
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The formation of ICLs can also be the result of endogenously occurring reactive aldehydes such as malondialdehyde, a natural product of lipid peroxidation of polyunsaturated fatty acids, and nitric oxide, which may induce diazotization of exocyclic amine groups of the bases (Scharer, 2005)
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