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Diabetes is a metabolic disorder that is characterized by a state of hyperglycemia, that occurs alongside dysregulations in insulin levels and in some cases, it arises concurrently to overweight and obesity (International Diabetes Federation, 2021)
Piercing Medical
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Upon activation, mast cells rapidly release pruritogenic mediators such as histamine, prostaglandin D 2 (PGD 2 ), tryptase, and β-hexosaminidase (Poto et al., 2022), which collectively stimulate C-type sensory nerve fibers and trigger neuroimmune amplification (Siiskonen and Harvima, 2019)
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