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SOD1 is a major intracellular Cu-binding protein localized in both the mitochondrial intermembrane space and the cytosol, requiring Cu and zinc as cofactors to regulate intracellular Cu homeostasis (Pansarasa et al., 2018)

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elegans led to the identification of a conserved and critical role for TRPA-1, in sensing MGO and also in SKN-1/Nrf2 activation to detoxify α-DCs