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Notably, this effect was reduced by the inhibitors of PI3k/Akt, indicating the significance of the PI3/Akt pathway in the cell growth stimulated by IGF-1 [5]

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The activation of epithelial to mesenchymal transition in hepatocytes results in loss of normal hepatic functions and regenerative capacity, where TGF-β signaling pathway play an important role (Xue et al., 2013)