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For instance, TSA is a class I/II HDAC inhibitors that can target multiple HDAC subtypes (including HDAC1, HDAC2, HDAC3, HDAC5, and HDAC6) and play a protective role in multiple kidney diseases (Table 4)

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unlike antibody-mediated endocytosis, cellular uptake is highly variable, depending critically on the intrinsic trafficking of the target protein or on non-specific pinocytosis, representing a major bottleneck in achieving therapeutically relevant intracellular concentrations of the PROTAC payload (Table 2) [244]