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Radiance
Number of Tests:50 Assays
Conclusions The convergence of ferroptosis, mitochondrial damage, and cerebral metabolic remodeling establishes a self-amplifying pathological triad in depression through three interlocked mechanisms: (1) GPX4 inactivation-driven lipid peroxidation disrupts neuronal membrane integrity while impairing mitochondrial respiratory chain complexes (I/III/IV) and releasing DAMPs that activate microglial NLRP3 inflammasomes
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