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Omega-3 PUFAs induce the Nrf2 transcription factor (TF) which, in turn, promotes the synthesis of antioxidant enzymes such as GPX4
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[8] Patients with diabetes mellitus should use ALA with caution because ALA can enhance glucose utilization and insulin sensitivity, potentially leading to hypoglycemia (low blood sugar) if used alongside insulin or oral antidiabetic drugs
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