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In addition to the lack of functional NNT in C57BL/6J mice (Ronchi et al., 2013), they also lack the stop codon for the NADK2 gene, resulting in a longer, potentially unstable mitochondrial protein (Timmermans and Libert, 2018) that may further contribute to the dysfunctional mitochondrial NADPH generation and antioxidant function

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Clinically, aggresomes have received much attention owing to their biochemical and morphological similarities to the misfolded protein inclusion bodies observed in the cytoplasm of neuronal cells affected by many neurodegenerative diseases