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Lycopene has been shown to antagonize oxidative stress damage and protect neurons, and long-term intake of lycopene-rich foods can effectively prevent the occurrence or development of NDs 119 , 120
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Studies have shown that ACSL4-enriched exosomes can be phagocytosed by microglia, leading to the activation of the nuclear factor kappa-B (NF-κB) signaling pathway and polarization of microglia toward a proinflammatory M1 phenotype, thereby amplifying neuroinflammation (He et al., 2024)
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