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and –5.14 kg and –1.89 kg/m 2 at 6 months [43]

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Biologically, a biphasic curve like this often points to more than one mechanism operating at once, for example a growth-promoting signalling pathway that dominates at low concentrations, and a separate, damaging or growth-arresting effect, perhaps related to oxidative stress from excess free copper, that only becomes significant once concentration climbs high enough