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Two parallel nose-to-brain transport pathways have been described in research models: Olfactory pathway (olfactory) — a peptide applied to the olfactory epithelium in the upper part of the nasal cavity can be transported along the olfactory nerves directly to the olfactory bulb and further to the structures of the forebrain, bypassing the systemic circulation Trigeminal nerve pathway — the endings of the trigeminal nerve innervating the nasal mucosa constitute a second route of transport to the brain stem and further structures of the CNS For BPC-157, the intranasal route additionally opens a direction related to the brain-gut axis and vagal nerve signaling – a neuro context explored in the literature, in which a peptide of gastric origin is tested for bidirectional gut-brain communication