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Finally, it is crucial to explore the key enzymes involved in CAT production by gut microbiota metabolism and their regulatory factors, evaluate the therapeutic potential of engineered probiotics (e.g., CAT-synthesizing strains) or exogenous CAT delivery systems (e.g., cartilage-targeted nanocarriers) for OA, and provide multi-level evidence for CAT-targeted OA therapy based on the gut-joint axis
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[DOI] [PMC free article] [PubMed] [Google Scholar] 3.Marques A.P., Santo A.S.D.E., Berssaneti A.A., Matsutani L.A., Yuan S.L.K
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