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doi: 10.1016/j.jbc.2024.107753 178 HouYXieJWangSLiDWangLWangHet al

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1 Introduction The unprecedented pace of industrialization and urbanization over recent decades has introduced a vast array of chemical contaminants into our environment, among which environmental endocrine disruptors (EEDs) have emerged as a particularly concerning threat to human reproductive health ( 1.1 Sources and classification of EEDs Environmental endocrine disruptors encompass a remarkably diverse array of chemical compounds that can be systematically categorized into three distinct groups based on their origin, chemical properties, and environmental behavior: Heavy Metals and Metalloids represent one of the most persistent categories of reproductive toxicants