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However, CaNa 2 EDTA can cause renal toxicity (at the proximal tubule particularly), especially during repeated high doses treatment (above 75 mg/kg) and in subjects with previous history of kidney damage [29]

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However, all three imaging agents proved to be stable in vivo and boasted relatively similar pharmacokinetic profiles in mice bearing GRPR-expressing PC-3 prostate cancer xenografts, suggesting that (at least in this case) the linker does not play a dramatic role in determining in vivo performance