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A recent study also shows that blocking IGF1R-mediated signaling reduces cell proliferation and increases cells sensitivity to the destructive effects of ionizing radiation mediated by down-regulation of BRCA2, a mediator of HR, suggesting that IGF1R is a target for enhancing tumor sensitivity to radiotherapy (Venkatachalam et al., 2017)
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(PubMed) Forman JP, Choi H, Curhan GC
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