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Other potential mechanisms underlying the action of NAC on neuropathic pain include the activation of type-9 matrix metalloprotease and the decreased phosphorylation of p38 MAP kinase in the spinal cord [167, 168]
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In summary, differentiating the exogenous and endogenous sources of HTyr in the body becomes a difficult task owing to a wide distribution of HTyr, its short plasma half-life and its possible interaction with different ways such as the dopamine pathway [117]
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