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Pascual et al., 2004), defective astroglial glutamate transportation (Rönnbäck and Hansson, 2004), hypoxia (Gibson et al., 1981), diabetes (Richardson, 1990), heart failure (Riegel et al., 2002), reduced glucose tolerance (Vanhanen et al., 1997), bradycardia, hypotension (Ackerman, 1996), stroke (van der Zwaluw et al., 2011), hypothermia, alcohol intoxication, thiamine and vitamin C deficiency, sedative-hypnotic drugs, opioids consumption (Martindale et al., 2010), general anesthesia (Parikh and Chung, 1995

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Tissue Repair and Cellular Regeneration As stated in the article The Human Tripeptide GHK and Tissue Remodeling in the Journal of Biomaterials Science, Polymer Edition, GHK-Cu stimulates cell signaling responsible for tissue remodeling, wound healing, and the maintenance of the extracellular matrix