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On the day of treatment: The area is cleansed and marked A local anaesthetic is applied for comfort The filler is injected using cannulas or needles, depending on technique The practitioner carefully shapes and sculpts the area for symmetry The procedure usually takes 45–90 minutes , depending on the amount of filler used

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19–22 These genetic polymorphic sites include rs3333631, rs763035, and rs111314066, which can exacerbate the inflammatory response in patients with rosacea by upregulating the expression of factors related to inflammatory pathways, such as Toll-like receptors and the JAK3 pathway