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This medication is indicated in states of vitamin B12 deficiency such as: pernicious anemia (reduction in the number of red blood cells due to vitamin B12 deficiency), pregnancy, malabsorption syndrome (difficulty in digesting nutrients from food that may be accompanied by diarrhea and colic), sprue (inflammation of the small intestine due to intolerance to gluten and other grains, causing diarrhea), regional enteritis (chronic inflammation of the digestive tract, small intestine, and colon), intestinal or pancreatic neoplasms (tumors), total or partial gastrectomy (removal of all or part of the stomach), and other conditions where there is a significant increase in the requirements of this vitamin

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A 2025 narrative review noted no adverse effects in the human cystitis study it referenced, and it reported no teratogenic, genotoxic, or anaphylactic effects identified in the available preclinical and limited human data