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Many distance restraints between the C-terminal half of the TM helix and the amphipathic C-terminal region of the protein were obtained, indicating that the Gly-Pro sequence had been brought to the hydrophilic/hydrophobic interface, something that would not be possible in a TM topology in a lipid bilayer
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In an essay of neurotrophic activity, Dihexa was found to be seven orders of magnitude more potent than BDNF
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