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Metabolites such as peptides, lipids, fatty acids, or amino acids can vary profoundly in polarity, size, and concentration, from hydrophilic, polar metabolites with low molecular weight, to hydrophobic, non-polar high-molecular-weight metabolites, providing extensive information on the physiological state and metabolic pathways [10,13,14]
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However, the precise mechanisms by which SCFAs influence brain physiology and behavior remain to be fully clarified, underscoring a promising avenue for developing novel CNS therapies
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