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DR was shown to induce the expression of SIRT1 in macrophages, resulting in anti-inflammatory M2 polarization that was shown to be required for the DR-mediated browning of WAT [55]
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However, current evidence is mainly derived from preclinical studies, and further investigations, particularly rigorous clinical trials in humans, are necessary to clarify the mechanisms involved and to evaluate their efficacy and safety in patients with cutaneous melanoma
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