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Moreover, MPST has -SH groups in its active center, which can undergo reversible or irreversible oxidation to -SOH, -SO 2 H, or -SO 3 H [37], (R2) and (R3) either by the direct reaction of the enzyme with DMSO or indirect reaction with products (such as reactive oxygen species) of its metabolism

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This requires careful selection of populations who are most likely to benefit, such as older adults with low serum 25(OH)D levels, sedentary lifestyles, or mild cognitive impairment, as well as standardized intervention protocols that allow clearer interpretation

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