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Additionally, the expression of glucose regulated protein 78 (GRP78) and CHOP, both key hallmarks of ERs, is dramatically enhanced, and the IRE1α/TRAF2/JNK signaling pathway is activated, which in turn increased the expression of Bax and inhibited the expression of Bcl-2, leading to hepatocyte apoptosis [8, 25]

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As a consequence, it is important for the robust diagnosis of radiation-induced GHD, ensuring the GH replacement therapy can be implemented at the right time