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Citing significant, unresolved safety risks, a total lack of robust human clinical efficacy data, and grave concerns over immunogenicity and peptide-related impurities, the FDA officially designated 19 of the most popular therapeutic peptides—explicitly including BPC-157, TB-500 (Thymosin beta-4 fragment), and injectable GHK-Cu—as “Category 2” bulk drug substances
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This review will focus on current strategies for antagonizing GH function and the related disease indications and will discuss considerations associated with an increasingly complex GH signal transduction network
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