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The system L-type (leucine-preferring) amino acid transporter LAT1 is an amino acid antiporter, mediating the influx of BCAAs and bulky amino acids (phenylalanine, methionine, histidine, tryptophan, and tyrosine) into cells 116,117 in exchange for efflux of intracellular substrates (EAA or glutamine) (Fig
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