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LIST OF ABBREVIATIONS ALS Amyotrophic Lateral Sclerosis ASD Autism Spectrum Disorders ATEC Autism Treatment Evaluation Checklist AUCB Autologous Umbilical Cord Blood BDNF Brain-derived Neurotrophic Factor BM-MSCs-CM BM-MSCs Conditioned Medium BMMNCs Bone Marrow-derived Mononuclear Cells BMMSCs Bone Marrow Mesenchymal Stem Cells BMSCs Bone Marrow Derived Stem Cells BTBR BTBR T+Itpr3tf/J CARS Childhood Autism Rating Scale CBMNCs Cord Blood Mononuclear Cells CGI-I Clinical Global Impression-improvement CHOOSE CRISPR-human Organoids-single-cell RNA Sequencing DPSCs Dental Pulp-derived Stem Cells EEG Electroencephalography EPCs Endothelial Progenitor Cells ESCs Embryonic Stem Cells FDA Food and Drug Administration FMRP FMR Protein GABA Gamma-aminobutyric Acid GAD Glutamate Decarboxylase GARS-II Gilliam Autism Rating Scale-second Edition hAECs Human Amniotic Epithelial Cells hASCs Human Adipose-derived Stem Cells hCT-MSCs Human Cord Tissue Mesenchymal Stromal Cells HSCs Hematopoietic Stem Cells hUC-MSCs Human Umbilical Cord MSCs iPSCs Induced Pluripotent Stem Cells ISAA Indian Scale for Assessment of Autism MIA Maternal Immune System Activation mPFC Medial Prefrontal Cortex MS Multiple Sclerosis MSC-exo Exosomes Secreted from MSC MSCs Mesenchymal Stem Cells NPCs Neural Progenitor Cells PBMC Peripheral Blood Mononuclear Cells PD Parkinson’s Disease PTEN Phosphatase and Tensin Homolog PV Parvalbumin-positive SHED Stem Cells From Human Exfoliated Deciduous Teeth SOD2 Superoxide Dismutase 2 TSC Tuberous Sclerosis Complex UCMSCs Umbilical Cord-derived Mesenchymal Stem Cells VPA Valproic Acid AUTHOR’S CONTRIBUTIONS The authors confirm their contribution to the paper as follows: YL, YL, JL, and MG wrote the draft of the manuscript