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Research Evidence Comparison# Retatrutide Research# The pivotal Phase 2 trial (Jastreboff et al., NEJM 2023) enrolled 338 adults with obesity and demonstrated weight reductions of up to 24.2% at 48 weeks
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Despite advancements in treatment—including chemotherapy, targeted therapy with epidermal growth factor receptor antibodies, and immunotherapy with immune checkpoint inhibitors—many CRC cases exhibit intrinsic or acquired resistance to cancer treatment, leading to limited treatment efficacy and high recurrence rates
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