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Post-translational modifications of the E2 and E3 subunits, including modification of the E2 subunitโs lipoic arms by glutathionylation, reactive oxygen species (ROS), and lipid peroxidation products, as well as cysteine oxidation and nitrosylation of the E3 subunit, have also been reported to modulate the activity of ฮฑ-ketoacid dehydrogenase complexes 5,6,7,8,9,10
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