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On the other hand, valproic acid is detrimentally associated with metabolic anomalies, including higher levels of insulin and triglyceride, weight gain and increased body mass index [268], similar to antipsychotics
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secondly, the activation of transcription factors that promote cell defense [10], and thirdly, enhanced production of eicosanoids and SPMs (specialized pro-resolving mediators) which are powerful short-range hormones modulating inflammation, immune response, and reproductive process, and are derived from ω-3 LCPUFA
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