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Similarly, in targeted metabolomics studies of urine, previous studies have targeted the abnormalities of reactive oxidative stress, gut bacteria metabolism, 239 amino acid (tyrosine, tryptophan, arginine, proline, methionine, cysteine, and taurine), lipid (phospholipid, sphingolipid, and fatty acid), urea cycle, xenobiotics metabolism, 239 , 240 TCA cycle, and glutamate metabolism 240 in urine of ASD

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A requisite for the innovation of de novo treatments for either disease prevention or modification is a comprehensive understanding of the spectrum of signaling pathways responsible for fibrosis in PD