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Although the etiology of IBD remains unknown, it is believed that a cocktail of genetic factors, environment, intestinal microbiota, and immune responses are to blame (136)
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For experimental applications, pharmacological GPX4 inhibitors such as RSL3 and ML162 are widely used to induce ferroptosis, enabling mechanistic studies of lipid peroxidation, redox regulation, cancer vulnerability, and ferroptosis-targeted therapeutic strategies [11] [12]
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