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However, the disruption of the BBB can result in considerable harm to the brain, as the BBB serves as a crucial protective barrier for the human brain [13]
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38–40 When free radicals attack intestinal epithelial cells (IECs) and cause damage, the death of IECs increases, the expression of intestinal tight junction proteins decreases, and the permeability of the epithelial barrier increases, which lead to the invasion of intestinal bacteria and other antigens into the intestinal mucosa
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