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The effect of TQ on the gene expression of TNF-α, NF-κB, and SIRT1 The level of testicular TNF-α and NF-κB transcription was significantly upregulated ( p ˂ 0.001) in the hypothyroid rats, while it showed a significant downregulation ( p = 0.001, p ˂ 0.001) in TQ-hypothyroid rats when compared to the untreated hypothyroid rats (Figure 1)
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In addition, in vitro and in vivo safety evaluations of Fer-1 liposomes were performed, and the results revealed that they had no significant toxic side effects (159, 160)
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