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In this reaction, 5-methyl-tetrahydrofolate transfers its methyl group to cobalamin (vitamin B12) to form methyl-cobalamin bound to MS and activates the enzyme 4
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However, a recent study found that AIFM2 had a marked inhibitory effect on GPX4 deficiency that leads to ferroptosis, renamed “FSP1” ( NAD(P)H is also indispensable for reducing GSSG to GSH
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