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It enhances growth hormone receptor expression and several pathways involved in cell growth and angiogenesis, and increases nitric oxide production by upregulating nitric oxide synthase (NOS) gene and protein expression

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joint involvement with pain/swelling/erythema), in the context of the patient’s history, with supporting evidence of elevated serum urate levels at a time other than during an acute attack Elevated serum urate levels alone are not diagnostic of gout, but may inform lifestyle changes (if relevant) and subsequent follow-up testing Treat gout flares with a NSAID, prednisone or low-dose colchicine