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We summarized the known posttranslational modifications and sites on NNMT in Table 2, which were obtained from the iPTMnet Website ( The interactome of NNMT We examined the interacting proteins of NNMT using the STRING database [35] ( showing that NNMT interacts with the following proteins including caveolae-associated protein 1 (PTRF), aldehyde oxidase (AOX1), epidermal growth factor receptor (EGFR), four and a half LIM domains protein 2 (FHL2), nicotinamide phosphoribosyltransferase (NAMPT), NAD-dependent protein deacetylase sirtuin 1-7 (SIRT1-7), ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 (BST1), and ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38) in human and mice