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This unbalance is in keeping with our PsA cohort clinical features, in which the most recorded metabolic comorbidities (see Table 1) were obesity (35.9%), hypertension (23.1%), hypercholesterolemia (12.8%), DT2 (15.4%) and metabolic syndrome (15.4%)
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In addition, PIEZO1 triggers an influx of calcium in intestinal epithelial cells, which leads to mitochondrial dysfunction and activates the NLRP3 inflammasome
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