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Studies have demonstrated that the inhibition of the MAPK/ERK pathway can promote oligodendrocyte generation and recovery in demyelinating diseases, suggesting a potential therapeutic approach for DN (Suo et al., 2019)
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However, these experiments with propargylglycine likely overestimated CSE contribution relative to CBS because the reaction mixtures did not contain S-adenosylmethionine or homocysteine, either of which would be needed for optimal levels of CBS-catalyzed Cys desulfuration
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