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After oncogene expression was induced by adenovirus expressing Cre recombinase for 12 weeks, mice were randomly treated with vehicle, trametinib, or sulfasalazine for an additional 4 weeks (Figure 4A)

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In contrast, resveratrol, a naturally occurring small molecule that induces metabolic benefits resembling CR, increases mitochondrial biogenesis, partly through activation of SIRT1 and PGC1α