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One aspect of the invention pertains to small molecule quinoline derived cations of Formula I, wherein: R 1 is C 1-4 alkyl
1000 mcg
mg:100mg
Based on evidence from clinical studies, the USPHS, AAP, and ACOG recommend a folic acid intake of 0.4 mg/day PO from food and/or supplements in females during the child-bearing years, and 0.6 mg PO daily throughout pregnancy
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