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While some researchers had used age, age of diagnosis, C-peptide, BMI, and HOMA values to assess insulin requirement and renal complications (33), our results suggested that the use of GADA and CP could identify Chinese patients with T2D in need of early insulin requirement with special attention to avoid risk of severe hypoglycemia
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This is because while rat lenses have high levels of aldose reductase activity and low levels of sorbitol dehydrogenase activity [34,35], human lenses exhibit low aldose reductase activity and high sorbitol dehydrogenase activity [34]
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