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2 Ferroptosis: core biochemistry and regulatory networks relevant to bone repair 2.1 Defining features and molecular mechanisms of ferroptosis Ferroptosis is a form of regulated cell death mechanistically distinct from apoptosis, necroptosis, and autophagic cell death ( At its core, the ferroptotic cascade follows a clear causal logic: catalytically active ferrous iron (Fe 2+ ) drives Fenton-type reactions that generate hydroxyl radicals (⋅OH) and other reactive oxygen species