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Their therapeutic effects primarily involve strengthening antioxidant defenses by enhancing GPX4 and GSH activity, reducing ROS accumulation, and limiting iron-induced lipid damage, thereby protecting hepatocytes
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This pattern is consistent with notable patterns of coexisting histone marks in human cells, such as ‘H3K4me2/3 + H4K16ac’ and ‘H3K4me2/3 + H3K9/14/18/23ac’, which have been supported by chromatin immunoprecipitation (ChIP) and mass spectrometry (MS) methods
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